Endocrine Abstracts

Introduction: After a period of enthusiasm for the early detection of cancer, apparently we are entering a period of skepticism, questions and side effects in the form of unnecessary operations and their complications and costs. This also applies to thyroid cancer, and actually nodules and lesions visible only in ultrasoundMethod. Prospective observation of consecutive patients in one centre.Results: In Years 2013 and 2014 we have performed 2189 ultrasou...

Introduction: Temozolomide (TMZ) can be administered as the last therapeutic option for aggressive pituitary tumors. Dopamine-agonist resistant prolactinomas are relatively frequent and remain a serious therapeutic problem. GH expressing atypical adenomas are rare and their positive response to TMZ is low. In a general opinion a lack of response to TMZ after three cycles predicts the treatment resistance.The aim of the study was presentation of two patie...

Introduction: Fine needle aspiration of thyroid nodules is the most frequently performed ambulatory and recommendations for its performance are quite accurately described in the national and international guidelines. However, there is always a need to analyze the effectiveness of such proceedings.The aim of this study was to analyze such effectiveness in group of hospitalized patients.Method: The reason for hospitalization in the v...

Insulin resistance affects 50–70% of women with polycystic ovary syndrome (PCOS).The aim of our study was to estimate the prevalence of insulin resistance by different methods in a single cohort of 63 PCOS patients diagnosed by the Rotterdam criteria.Methods: Anthropometric measurement, examination and fasting blood tests were made on the 3–5th days of their periods. HOMA-IR (cut off >2.5) and QUICKI (cut off <0.3...

Introduction: Turner syndrome (TS) is a condition caused by structural or numerical abnormalities of X chromosome. Growth deficiency is characteristic for patients with TS, and particular karyotype abnormalities of the X chromosome may be associated with different responsiveness to human GH (hGH) therapy. The aim of the study was to determine the effect of TS karyotype on growth velocity during hGH therapy in TS.Methods: 23 TS patients treated with hGH w...

Introduction: Data regarding the thyroid gland evaluation in Polish adolescents are limited.Aim: The aim of the study was to asses TSH and anti-thyroid peroxidase antibodies (anti-TPO) concentrations as well as thyroid morphology on ultrasound in Warsaw adolescents in regard of family history of thyroid disease.Materials and methods: The study was carried out on a group of 480 adolescents (285 girls and 195 boys), aged 17–18 y...

Background: The activating somatic point mutation, BRAFV600E, is the most common genetic alteration observed in papillary thyroid carcinoma (PTC) but its oncogenic role in PTC has been extensively investigated. Numerous studies reported that BRAFV600E correlates with poor clinical outcome, whereas others have found no such association. It is estimated that BRAFV600E occurs in ~ 45–50% of PTC cases, but recent studies showed the more freque...

Introduction: Copeptin can be used as a tool to directly assess serum antidiuretic hormone (ADH) level. A certain pool of ADH are synthesized in hypothalamus, together with corticoliberin (CRH). Then they are released into the pituitary portal circulation, where through the V1bR receptor ADH stimulates adrenocorticotropic cells and ACTH secretion, followed by cortisol and catecholamines production. The stimulus for ADH secretion is, among others, stress. In turn, presynaptic s...

Introduction: Pregnancy in an acromegalic woman is rare and generally safe, but tumor expansion may occur. As this is a rare occurrence, little is known about the optimum management of such patients during pregnancy. We present the case of a woman with acromegaly treated with Lanreotide during pregnancyCase report: A 29-year-old woman with acromegaly underwent transsphenoidal resection of invasive pituitary macroadenoma in August 2014, without cure. In N...

Introduction: Abnormalities in cell cycle pathways, such as CDKN1B (p27) underexpression, have been identified in the pathogenesis of pituitary adenomas, but their underlying mechanisms have not been elucidated. Ribosomal proteins have been recently related to pituitary tumorigenesis. In gastric cancer, RPS13 down-regulates p27 and promotes cell cycle progression; these mechanisms have not yet been explored in pituitary adenomas.Objective: To evaluate th...